CHEM/BCMB 4190/6190/8189

Introductory NMR

(Fall 2006)


Nuclear Magnetic Resonance (NMR) is a form of spectroscopy that uses the magnetic properties of nuclei to probe molecular structure. It has found applications in analysis of organic and inorganic compounds, in structure determination of biological macromolecules, and even in medical imaging. This introductory course is intended to serve a broad audience seeking a background in principles behind NMR methodology as well as a practical introduction to how data are acquired and analyzed. Material is presented partly in lecture and partly in laboratory formats. It is an ideal stepping-stone to more advanced courses offered in biomolecular NMR (CHEM/BCMB 8190) as well as other application-oriented courses.

The three courses share lecture and laboratory presentations. Grading is based on exams, a comprehensive final exam, written laboratory reports, and an evaluation of classroom and laboratory participation. For 8189, completion of an additional independent study project is required.


Internet Links

Problem Sets

Notices

Instructor:
Jeffrey Urbauer



Class Time:
TU, TH, 3:30-4:45

Inquiries to Professor Urbauer -
urbauer@chem.uga.edu


Recommended text:


"Basic One- and Two-Dimensional NMR Spectroscopy"
-VCH paperback

web notes
     class notes
Course Syllabus 
Laboratory Sessions
Exams
Holidays (no class)
Date
  Topic
Text Readings
     

Aug.

TH 17

 

Introduction and Basic Principles I

 

1.1, 1.2

TU 22 Basic Principles I graphic

1.2, 1.3

TH 24 Basic Principles II   another link
       1.4 - 1.6
TU 29 1H and 13C Chemical Shifts notes  another link

2.1 - 2.4

TH 31 1H/1H, 13C/1H, 13C/13C Couplings notes

3.1 - 3.5

Sept.

 

 

 

 

 

TU 5 1D 1H NMR Lab #1      lab three 
TH 7 1D 1H NMR Lab #1
TU 12
EXAM 1

 

TH 14 Double Resonance Experiments notes

5.1 - 5.3

TU 19
Spin Relaxation notes
       7.1 - 7.3
TH 21 Intro to Complex Pulse Sequences
       8.1, 8.2
TU 26 1D Double Resonance NMR Lab #2 second lab file
TH 28 1D Double Resonance NMR Lab #2

Oct.

 

 

 

 

TU 3
EXAM 2
 
TH 5 Spin-Echo Experiment

8.3, 8.4

TU 10 INEPT Experiment  

8.5

TH 12 DEPT Experiment

8.6

TU 17 1D 13C and DEPT NMR Lab #3
TH 19 1D 13C and DEPT NMR Lab #3
TU 24
Special Topic
TH 26
FALL BREAK    NO CLASS
TU 31

Introduction to 2D NMR / COSY notes

9.1, 9.2

Nov.

TH 2

 

  EXAM 3

 

 

TU 7 2D COSY / HETCOR

9.4

TH 9 2D TOCSY / HSQC

9.4

TU 14 2D HSQC / COSY Lab #4 NOTES  NOTES     
TH16 2D HSQC / COSY Lab #4
TU21 The Nuclear Overhauser Effect NOTES        10.1, 10.2
   

 

TH 23
THANKSGIVING HOLIDAY - NO CLASS
TU 28
2D NOESY notes  

Dec.

 

 

TH 30 2D TOCSY NOESY HSQC Lab #5 bites   button       10.2 - 10.4
TU 5 HSQC Lab #5
TH 7
Paramagnetic effects  
TU 12
Reading day  
TH 14
Final Exam (3:30 - 6:30)


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