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| Lecture Schedule | |||
| Date | Instructor | Topic | Suggested Reading |
| L – Levitt C – Cavanagh | |||
| I. Introduction | |||
| M 1/09 | Prestegard | A. Magnetic properties of nuclei and electrons - precession | 5 – 32 L |
| W 1/11 | Prestegard | 32 – 46 L, 626 – 627 L | |
| II. Instrumentation | |||
| M 1/16 | MLK Jr. Holiday (no class) | ||
| W 1/18 | Prestegard | A. Instrumental considerations - a look at probes | 72 – 87 L |
| M 1/23 | Prestegard | B. Fourier transform methods and data Processing | 89 – 122 L |
| III. NMR Observables – Classical and Quantum Descriptions | |||
| W 1/25 | Prestegard | A. Spin operators and their time dependence | 169 – 184 L |
| M 1/30 | Prestegard | B. Scalar Couplings | 211 – 216 L |
| W 2/01 | Prestegard | C. Spin Relaxation and NOEs Spin Relaxation Notes |
226 – 236 L, 588 – 594 L |
M 2/06 |
Prestegard | D. Chemical Shifts | 192 – 200 L |
| IV. Density Matrices and Product Operator Formalism | |||
W 2/8 |
Prestegard | 344 – 355 L | |
| M 2/13 | Prestegard | 355 – 356 L | |
| W 2/15 | Prestegard | C.Density Matrix in Product Operator Form | 357 – 384 L |
| V. Basic Pulse Sequences | |||
| M 2/20 | Prestegard | A. Coherence transfer in COSY | 388 – 398 L |
| W 2/22 | Prestegard | B. Basic heteronuclear experiments INEPT and HSQC | 418 – 434 L, 410 – 447 C |
| M 2/27 | Prestegard | C. TOCSY and NOESY | 543 – 569 L |
W 3/01 |
Prestegard | D. Extension to 3D | 447 – 467 C |
F 3/03 |
----- Midterm ----- | ||
| VI. Assignment Strategies: proteins and nucleic acids | |||
M 3/06 |
Urbauer | A.Triple resonance experiments for proteins | 468 – 530 C |
W 3/08 |
Urbauer | B. Sequential assignment strategies in proteins | 533 – 543 C |
| M 3/13 | Spring Break (no class) | ||
| W 3/15 | Spring Break (no class) | ||
| M 3/20 | Germann | C. Homonuclear assignment strategies for RNA and DNA |  |
| W 3/22 | Germann | D. Heteronuclear assignment strategies for RNA and DNA NOESY Solution |
|
| VII. Applications to Structure and Dynamics | |||
| M 3/27 | Urbauer | A. Structure determination protocols | 543 – 554 C |
| W 3/29 | Prestegard | B. Molecular motions in biomolecules | 513 -537 L |
| M 4/03 | Prestegard | C. Dipolar Coupling in Solids | 203 – 210 L |
W 4/05 |
Prestegard | D. Residual Dipolar Couplings | 425 – 432 L |
| VIII. Other Applications | M 4/10 | Prestegard | |
| W 4/12 | Prestegard | 557-564 L | |
| M 4/17 | Prestegard | C. MRS and metabolomics | |
| W 4/19 | Prestegard | D. Paramagnetic and Quadrupolar NMR | |
| M 4/24 | Yang | E. Chemical exchange rates | |
| IX. Advanced Techniques | |||
| W 4/26 | Yang | A. Protein folding, amide exhange rates |
488 – 504 L |
| M 5/01 | Prestegard | B. Review and Special Topics | |
F 5/05 |
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