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Lecture Schedule
    Wimba Classroom: Biomolecular NMR Spectroscopy - 2012  
       
Date Instructor TopicSuggested Reading
      L – Levitt    C – Cavanagh
I. Introduction
M 1/9 Prestegard A. Magnetic properties of nuclei and electrons - precession
[video of lecture from 2010]
5 – 38 L
W 1/11 Prestegard B. RF pulses and spin relaxation - Bloch equations
(precession video) [video of lecture]
39 – 50 L, 653 L
       
II. Instrumentation
M 1/16   MLK Jr. Holiday (no class)  
W 1/18 Prestegard A. Instrumental considerations - a look at probes
[video of lecture]
65 – 76 L
M 1/23 Prestegard B. Fourier transform methods and data processing
[video of lecture]
85 – 102 L
       
III. NMR Observables – Classical and Quantum Descriptions
W 1/25 Prestegard A. Scalar Couplings
[video of lecture]
217 – 223 L
M 1/30 Prestegard B. Chemical Shifts
[video of lecture]
195 – 206 L
W 2/1 Prestegard C. Intro to a quantum mechanical (QM) description of NMR
[video of lecture]
171 – 194 L
M 2/6 Prestegard D. Applications to second order spectra
[video of lecture]
615 – 623 L
       
IV. Density Matrices and Product Operator Formalism
W 2/8 Prestegard A. Density Matrix - Evolution and interpretation
[video of lecture]
259 – 289 L, 369 – 381 L
M 2/13 Prestegard B. Density matrix in product operator form
[video of lecture]
381 – 391 L
W 2/15 Prestegard C. 2D Heteronuclear Correlation
[video of lecture]
105 – 113 L, 436 – 443 L, 410 – 447 C
M 2/20 Prestegard D. COSY & TOCSY
[video of lecture]
409 – 418 L, 492 – 506 L
       
V. Basic Pulse Sequences
W 2/22 Prestegard A. Pulse field gradients & extensions to 3D
[video of lecture]
649 – 652 L, 114 L
M 2/27 Urbauer B. Triple resonance experiments for proteins
[video of lecture]
468 – 530 C
W 2/29 Urbauer C. Sequential assignment strategies in proteins
[video of lecture]
533 – 543 C
M 3/5 Prestegard D. Spin relaxation and NOEs
[video of lecture]
543 – 576 L
W 3/7 Prestegard E. Spin relaxation and TROSY
[video of lecture]
584– 593 L, 306 – 308 L
       
VI. Assignment Strategies and Structure Determination: Proteins and Nucleic Acids
M 3/12   Spring Break - no class  
W 3/14   Spring Break - no class  
M 3/19 Urbauer A. Structure determination protocols
[video of lecture]
543 – 554 C
W 3/21 Germann B. Homonuclear strategies for RNA and DNA
DNA Miniduplex (example spectrum)
[video of lecture]
 
M 3/26 Germann C. Heteronuclear strategies for RNA and DNA
[video of lecture]
 
       
VII. Advanced Techniques for Structure and Dynamics
W 3/28 Prestegard A. Dipolar Coupling and Solids NMR
[video of lecture]
211 – 217 L
M 4/2 Prestegard B. Residual Dipolar Coupling
[video of lecture]
443 – 454 L
W 4/4 Prestegard C. Paramagnetic Effects
[video of lecture]
 
M 4/9 Prestegard D. Drug Discovery, SAR by NMR, STD, Tr-NOE
[video of lecture]
 
W 4/11 Prestegard E. Metabolomics and in vivo Spectroscopy (MRS)
[video of lecture]
 
       
VIII. Other Applications
M 4/16 Yang A. Chemical Exchange and Diffusion
[video of lecture]
515 – 524 L
W 4/18 Yang B. Protein Folding and Amide Exchange
[video of lecture]
 
M 4/23 Prestegard C. Sensitivity Enhancement by Polarization Transfer
[video of lecture]
 
W 4/25 Zhao D. Imaging (MRI)
[video of lecture]
309 – 315 L
       
W 5/2   FINAL EXAM
UGA 8:00 - 11:00 in Life Sciences Bldg. Room B116