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Course Syllabus


Lecture Schedule
Wimba Classroom: Biomolecular NMR Spectroscopy - Spring 2014
       
Date Instructor TopicSuggested Reading
      L – Levitt    C – Cavanagh
I. Introduction
M 1/6 Prestegard A. Magnetic properties of nuclei and electrons - precession
[video of lecture] (no audio until 2:08)
5 – 38 L
W 1/8 Prestegard B. RF pulses and spin relaxation - Bloch equations
(precession video) [video of lecture]
39 – 50 L, 653 L
       
II. Instrumentation
M 1/13 Prestegard A. Instrumental considerations - a look at probes
[video of lecture]
65 – 76 L
W 1/15 Prestegard B. Fourier transform methods and data processing
[video of lecture]
85 – 102 L
M 1/20   MLK Jr. Holiday (no class)  
       
III. NMR Observables – Classical and Quantum Descriptions
W 1/22 Pederson A. Scalar Couplings
[video of lecture]   [video of 2012 lecture]
217 – 223 L
M 1/27 Prestegard B. Chemical Shifts
[video of lecture]
195 – 206 L
W 1/29 Prestegard C. Intro to a QM description of NMR
[video of lecture]
171 – 194 L
M 2/3 Prestegard D. Applications to second order spectra
[video of lecture]
615 – 623 L
       
IV. Density Matrices and Product Operator Formalism
W 2/5 Prestegard A. Density Matrix - Evolution and interpretation
[video of lecture]
259 – 289 L, 369 – 381 L
M 2/10 Prestegard B. Density matrix in product operator form
[video of lecture]
381 – 405 L
W 2/12 Prestegard C. 2D Heteronuclear Correlation
[video of lecture]
105 – 113 L, 436 – 443 L, 410 – 447 C
M 2/17 Prestegard D. COSY, TOCSY
[video of lecture]
409 – 418 L, 492 – 506 L
       
V. Basic Pulse Sequences
W 2/19 Prestegard A. Pulse field gradients and extensions to 3D
[video of lecture]
649 – 652 L, 114 L
M 2/24 Urbauer B. Triple resonance experiments for proteins
[video of lecture]
468 – 530 C
W 2/26 Urbauer C. Sequential assignment strategies in proteins
[video of lecture]
533 – 543 C
M 3/3 Prestegard D. Spin relaxation and NOEs
[video of lecture]
543 – 576 L
W 3/5 Pederson E. Residual Dipolar Coupling
[video of lecture]
443– 454 L
       
VI. Applications I
M 3/10   Spring Break - no class  
W 3/12   Spring Break - no class  
M 3/17 Prestegard A. Spin Relaxation in Proteins
[video of lecture]
584 – 593 L*, 306 – 308 L*
W 3/19 Germann B. NMR of RNA and DNA I
[video of lecture]
 
M 3/24 Yang C. Chemical Exchange and Diffusion
Part 1 of 2: [video pt. 1]    Part 2 of 2: [video pt. 2]
Note: There were technical difficulties during the lecture.
515 – 524 L*
W 3/26 Yang D. Protein Folding and Amide Exchange
[video of lecture]
 
M 3/31 Germann E. NMR of RNA and DNA II
[video of lecture]
 
W 4/2 Urbauer F. Structure Determination Protocols
[video of lecture]
543 – 554 C
M 4/7 Prestegard G. Imaging (MRI)
[video of lecture]
309 ‐ 315 L
W 4/9 Prestegard H. in vivo Spectroscopy (MRS)
[video of lecture]
 
       
VII. Applications II
M 4/14 Prestegard A. Sensitivity Enhancement by Polarization Transfer
[video of lecture]
 
W 4/16 Prestegard B. Drug Discovery, SAR by NMR, STD, Tr-NOEs
[video of lecture]
 
M 4/21 Prestegard C. Paramagnetic Effects
[video of lecture]
 
W 4/23 Prestegard D. Solids NMR
[video of lecture]
211 – 217 L
M 4/28 Prestegard E. Review – self-study – email questions  
       
F 5/2   FINAL EXAM (8:00 - 11:00) UGA