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| Lecture Schedule | |||
| Date | Instructor | Topic | Suggested Reading |
| L – Levitt C – Cavanagh | |||
| I. Introduction | |||
| M 1/07 | Prestegard | A. Magnetic properties of nuclei and electrons - precession | 5 – 32 L |
| W 1/09 | Prestegard | 32 – 46 L, 626 – 627 L | |
| precession of a gyroscope (movie) | |||
| II. Instrumentation | |||
| M 1/14 | Prestegard | A. Instrumental considerations - a look at probes | 89 - 122 L |
| W 1/16 | Prestegard | B. Fourier transform methods and data processing | 72 – 87 L |
| M 1/21 | Prestegard | MLK Jr. Holiday (no class) | |
| III. NMR Observables – Classical and Quantum Descriptions | |||
| W 1/23 | Urbauer | A. Scalar Couplings | 211 - 216 L |
| M 1/28 | Prestegard | A. Scalar Couplings - repeat | |
| W 1/30 | Prestegard | B. Chemical Shifts | 192 - 200 L |
| M 2/04 | Prestegard | C. Introduction to a QM description of NMR | 169 - 184 L |
W 2/06 |
Prestegard | D. Applications to second order spectra | |
| M 2/11 | Prestegard | E. Spin Relaxation and NOEs | 226 - 236, 588 - 594 L |
| IV. Density Matrices and Product Operator Formalism | |||
W 2/13 |
Prestegard | 344 – 355 L | |
| M 2/18 | Prestegard | 355 – 356 L | |
| W 2/20 | Prestegard | C. RF Pulses and Evolution | 357 – 384 L | F 2/22 | MIDTERM |
| V. Basic Pulse Sequences | |||
| M 2/25 | Prestegard | A. Coherence transfer in INEPT and HSQC | 418 – 434 L, 410 – 447 C |
| W 2/27 | Prestegard | B. COSY, TOCSY and NOESY | 388 – 398 L, 543 – 569 L |
M 3/03 |
Prestegard | C. TOCSY and NOESY | 343 – 369 L |
| W 3/05 | Prestegard | D. Extension to 3D and Pulse Field Gradients | 447 – 467 C, 625 L |
M 3/10 |
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W 3/12 |
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| VI. Assignment Strategies: proteins and nucleic acids | |||
| M 3/17 | Urbauer | A. Triple resonance experiments for proteins | 468 - 530 C |
| W 3/19 | Urbauer | B. Sequential assignment strategies in proteins | 533 - 543 C |
| M 3/24 | Germann | C. Homonuclear assignment strategies for RNA and DNA Alternate verion of the notes for Windows based computers |
|
| W 3/26 | Germann | D. Heteronuclear assignment strategies for RNA and DNA | |
| VII. Applications to Structure and Dynamics | |||
| M 3/31 | Urbauer | A. Structure determination protocols | 543 – 554 C |
| W 4/02 | Prestegard | B. Molecular motions in biomolecules | 513 – 537 L |
| M 4/07 | Prestegard | C. Dipolar coupling in solids | 203 – 210 L |
W 4/09 |
Prestegard | D. Residual dipolar coupling and paramagnetic effects | 425 – 432 L |
| VIII. Other Applications | M 4/14 | Prestegard | |
| W 4/16 | Zhao | ||
| M 4/21 | Prestegard | C. MRS | |
| W 4/23 | Yang | D. Chemical exchange and diffusion | 488 - 504 L |
| M 4/28 | Yang | E. Protein folding and amide exchange | |
| Course Evaluation (UGA students) Course Evaluation (GSU and Tech Students) Fax to: 706-542-4412 |
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| W 4/30 | |||