Recent progress in sequencing of various genomes has uncovered thousands of proteins with little homology to characterized proteins, and hence, proteins with unknown function. The prospect of uncovering function through the acquisition of structural information (structural genomics) is appealing. NMR has a role to play in massive structure determination efforts, both as a screening tool for choice of structure determination protocol, and as a structure determination tool for non-crystallizable proteins. See our SECSG NMR web page for a status report on our screening project.