Publication Highlight

Glycan Conformation in the Heavily Glycosylated Protein, CEACAM1

Rogals, M. J., Eletsky, A., Huang, C., Morris, L. C., Moremen, K. W., and Prestegard, J. H.
ACS Chemical Biology (2022) 17:3527-3534.     (doi:10.1021/acschembio.2c00714)

Pseudo Contact Shifts (PCSs) provide long range (10-40 Å) distance information on the position of glycans attached to proteins. PCSs are easily measured from positions of crosspeaks 2D 1H-13C or 1H-15N solution NMR spectra. See what we have learned in the publication cited above.