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![SECSG](/images/secsg.png)
James H. Prestegard
Eminent Scholar of
NMR Spectroscopy
Professor of Chemistry
and Biochemistry
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Group Research Interests
Cell Surface Carbohydrates
Carbohydrates covalently linked to proteins and to lipids also
occur at the surfaces of membranes. They are, in fact, primary
mediators in processes that involve interaction of a cell with its
external environment. These include important processes such as
cell-cell interactions, hormone stimulation, and invasion by
pathogens. Structural characterization of the carbohydrate
moieties in their native environment is essential to understanding
and controlling the processes in which they are involved. Many of
the NMR methods being developed to characterize membrane proteins
are equally applicable to cell surface carbohydrates In addition,
methods that are more focussed at the details of protein-carbohydrate
recognition interactions are important. A number of lectins
from plant and animal sources are being studied as models
for these recognition processes, and as a testing ground for
methods that can characterize them.
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