Facility Links
James H. Prestegard
Eminent Scholar of
NMR Spectroscopy
Professor of Chemistry
and Biochemistry
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Group Research Interests
NMR Methods Development
Methods development in the Prestegard lab is closely connected
to the demands of our applications. For example, some exciting
diffusion edited amide exchange experiments have been developed for
the investigation of the energetics and kinetics of protons
involved in hydrogen bonds. Hydrogen bonding is important in
stabilizing protein structural elements and it is important in
protein-carbohydrate recognition, both subjects under study
elsewhere in the lab. Neural network based automated assignment
programs for multidimensional NMR spectra have been developed, as
have statistics based spectral analysis programs. These programs are
essential in making NMR based structural analysis less tedious and more
precise.
We are always on a quest to extract new types of information from NMR
and related experiments. Current projects involve the use of residual
dipolar couplings that occur in molecules oriented by very high magnetic
fields, and cross-correlation effects that involve chemical shift
anisotropies that also become large in high fields. Both topics rely
on the design of new experiments and an in depth theoretical analysis of
experimental results.
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